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Repeated Idazoxan Increases Brain Imidazoline Receptors in Normotensive (WKY) but Not in Hypertensive (SHR) Rats
Author(s) -
Olmos Gabriel,
Miralles Antonio,
Barturen Fernando,
GarcìaSevilla Jesús A.
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb06386.x
Subject(s) - idazoxan , imidazoline receptor , endocrinology , medicine , receptor , medulla oblongata , chemistry , hypothalamus , central nervous system , antagonist , prazosin
: The specific binding of [ 3 H]idazoxan in the presence of 10 −6 M (−)‐adrenaline was used to evaluate the density of imidazoline receptors in the brain of spontaneously hypertensive (SHR) rats and sex‐and age‐matched normotensive Wistar‐Kyoto (WKY) rats. In SHR rats the density of imidazoline receptors (cerebral cortex, hypothalamus, and medulla oblongata) was not different from that in normotensive (WKY) rats. However, repeated treatment with idazoxan consistently increased (23–80%) the density of imidazoline receptors in the various brain regions of WKY rats but not in SHR rats. In normotensive Sprague‐Dawley rats, repeated treatment with the imidazoline drugs idazoxan and cirazoline also increased (33–37%) the density of imidazoline receptors in the cerebral cortex. The lack of regulation by idazoxan of the density of imidazoline receptors in the brain of SHR rats might reflect the existence of a relevant abnormality of these receptors in this genetic model of hypertension.