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Differential Localization of Alternative Spliced Transcripts Encoding Inositol 1,4,5‐Trisphosphate Receptors in Mouse Cerebellum and Hippocampus: In Situ Hybridization Study
Author(s) -
Nakagawa Toshiyuki,
Shiota Chiyo,
Okano Hideyuki,
Mikoshiba Katsuhiko
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb06385.x
Subject(s) - in situ hybridization , cerebellum , inositol , biology , hippocampus , complementary dna , receptor , inositol trisphosphate receptor , microbiology and biotechnology , neuroscience , gene expression , genetics , gene
: Expression of inositol 1,4,5‐trisphosphate (Ins P 3 ) receptor subtypes was determined in mouse brain using oligonucleotide‐specific in situ hybridization. All subtypes, except one that deletes 120 bp from the full‐length Ins P 3 receptor cDNA, were expressed in cerebellar Purkinje cells. In hippocampus, various subtypes showed distinct expression patterns. These results suggest that regionally selective expression of InsP 3 receptor subtypes may result in the generation of functionally distinct channels.