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The Turnover of Rat Cortical α 1 ‐Adrenoceptors Is Not Modified by Repeated Electroconvulsive Treatment
Author(s) -
Nowak Gabriel,
Zak Joanna
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb03459.x
Subject(s) - electroconvulsive shock , turnover , receptor , medicine , endocrinology , chemistry , electroconvulsive therapy , protein turnover , affect (linguistics) , psychology , protein biosynthesis , biochemistry , communication , management , economics
The effect of repeated treatment with electroconvulsive shock (ECS) on the turnover of cortical α 1 ‐adrenoceptors in rats was measured using the N ‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ)‐induced irreversible receptor inactivation method. Repeated treatment with ECS did not affect parameters (the synthesis rate constant r , the degradation rate constant k ) of α 1 ‐adrenoceptor turnover. Because increase in the density of α 1 ‐adrenoceptors in the ECS‐treated group disappears later during measurement of turnover, several calculation possibilities were discussed. The present data confirm that repeated treatment with ECS produces a short‐lasting up‐regulation of cortical α 1 ‐adrenoceptors, but does not affect the turnover of this receptor type.