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Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains
Author(s) -
Sofic E.,
Paulus W.,
Jellinger K.,
Riederer P.,
Youdim M. B. H.
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb02017.x
Subject(s) - substantia nigra , pars compacta , lipid peroxidation , chemistry , dopamine , basal ganglia , pars reticulata , medicine , biochemistry , endocrinology , biology , antioxidant , central nervous system , dopaminergic
Abstract: Histochemical and biochemical determinations of total iron, iron (II), and iron (III) contents in brain regions from Parkinson's and Alzheimer's diseases have demonstrated a selective increase of total iron content in parkinsonian substantia nigra zona compacta but not in the zona reticulata. The increase of iron content is mainly in iron (III). The ratio of iron (II):iron (III) in zona compacta changes from almost 2:1 to 1:2. This change is thought to be relevant and may contribute to the selective elevation of basal lipid peroxidation in substantia nigra reported previously. Iron may be available in a free state and thus can participate in autooxidation of dopamine with the resultant generation of H 2 O 2 and oxygen free radicals.