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Cholecystokinin Modulates the Release of Dopamine from the Anterior and Posterior Nucleus Accumbens by Two Different Mechanisms
Author(s) -
Marshall F. H.,
Barnes S.,
Hughes J.,
Woodruff G. N.,
Hunter J. C.
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb02009.x
Subject(s) - nucleus accumbens , cholecystokinin b receptor , cholecystokinin , dopamine , endocrinology , medicine , chemistry , antagonist , cholecystokinin receptor , receptor , biology
The effects of various cholecystokinin (CCK)‐related peptides were investigated on 35 m M K + ‐stimulated endogenous dopamine release from slices of either anterior or posterior nucleus accumbens of the rat. CCK sulphated octapeptide (1–10 μ M ), but not pentagastrin or CCK unsulphated octapeptide, was found to cause a dose‐dependent increase in the release from the posterior nucleus accumbens. This effect was blocked by low doses of the CCK A receptor antagonist L364,718 (10 n M ) but not the CCK B receptor antagonist L365,260. In the anterior nucleus accumbens CCK sulphated octapeptide (1 μ M ) and CCK unsulphated octapeptide (0.1–1 μ M ) inhibited the dopamine release, and this effect was blocked by L365,260 (10–100 n M ) but not by L364,718. These results suggest that CCK has a different effect on dopamine release from the anterior and posterior nucleus accumbens and that these effects are mediated by two different types of CCK receptor.