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Role of Dopaminergic Neurons in Denervation‐Induced α 1 ‐Adrenergic Up‐Regulation in the Rat Cerebral Cortex
Author(s) -
Nowak Gabriel,
Zak Joanna,
Superata Jerzy
Publication year - 1991
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1991.tb02008.x
Subject(s) - dopaminergic , denervation , lesion , oxidopamine , prazosin , neuroscience , cerebral cortex , medicine , desipramine , dopaminergic pathways , endocrinology , dopamine , chemistry , biology , receptor , hippocampus , antidepressant , antagonist , substantia nigra , pathology
The density of [ 3 H]prazosin binding to α 1 ‐adrenoceptors in the rat cortex was measured after selective and mixed noradrenergic or dopaminergic lesions. DSP‐4 produced a selective noradrenergic lesion and increased the density of α 1 ‐adrenoceptors. 6‐Hydroxydopamine produced a selective dopaminergic lesion (after desipramine protection of noradrenergic neurons) and a mixed noradrenergic and dopaminergic lesion that did not change the cortical α 1 ‐adrenoceptor binding. On the basis of the results obtained, a hypothesis is put forward that the central dopaminergic system controls the denervation‐induced cortical α 1 ‐adrenoceptor up‐regulation.