Premium
5‐Hydroxytryptamine Amplifies β‐Adrenergic Stimulation of N ‐Acetyltransferase Activity in Rat Pinealocytes
Author(s) -
Sugden David
Publication year - 1990
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1990.tb04952.x
Subject(s) - pinealocyte , stimulation , acetyltransferase , receptor , adrenergic , endocrinology , 5 ht receptor , medicine , melatonin , chemistry , serotonin , biology , pineal gland , biochemistry , gene , acetylation
In cultured rat pinealocytes β‐adrenergic induction of N ‐acetyltransferase, a key enzyme in the synthesis of melatonin, is amplified by addition of 5‐hydroxytryptamine (5‐HT) to the culture medium. However, 5‐HT when added alone has no effect on enzyme activity. Pharmacological experiments with a range of agonists and antagonists suggest that this action is not mediated by 5‐HT 1 , 5‐HT 2 , 5‐HT 3 , or 5‐HT 4 receptor subtypes but may involve a site similar to the 5‐HT ip receptor described in the enteric nervous system. The potential role of 5‐HT in modulating adrenergic stimulation of N ‐acetyltransferase activity is discussed.