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Different Ceramide Compositions of Gangliosides Between Human Motor and Sensory Nerves
Author(s) -
OgawaGoto K.,
Funamoto N.,
Abe T.,
Nagashima K.
Publication year - 1990
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1990.tb04930.x
Subject(s) - ceramide , ganglioside , myelin , sensory system , motor nerve , axon , sensory nerve , chemistry , biochemistry , sphingolipid , biology , neuroscience , central nervous system , apoptosis
Ganglioside analysis of human motor and sensory nerves revealed that ceramide compositions of sensory nerve GD1a, GD1b, and GMl differed apparently from those in the motor nerve. These gangliosides from sensory nerve contained a large amount of long‐chain fatty acids and d18:1 as a major long chain base. On the contrary, the motor nerve gangliosides contained C 16–18 fatty acids and a large amount of d20:1 besides d 18:1. Furthermore, these gangliosides were enriched more in the axon fraction than in the myelin fraction. LM1, which was a major ganglioside in myelin from human peripheral nerve, was composed of similar ceramide compositions in the two nerves. The present findings suggest that the characteristic ceramide species of nerve gangliosides may reflect in part properties of their own neurons.