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Effect of Transient Cerebral Ischaemia and Cardiac Arrest on Brain Extracellular Dopamine and Serotonin as Determined by In Vivo Dialysis in the Rat
Author(s) -
Sarna G. S.,
Obrenovitch T. P.,
Matsumoto T.,
Symon L.,
Curzon G.
Publication year - 1990
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1990.tb04581.x
Subject(s) - homovanillic acid , dopamine , medicine , serotonin , endocrinology , ischemia , microdialysis , striatum , dopaminergic , in vivo , extracellular , 5 hydroxyindoleacetic acid , hippocampal formation , chemistry , anesthesia , biology , biochemistry , receptor , microbiology and biotechnology
The effects of 20‐min transient, global, forebrain ischaemia and cardiac arrest on extracellular concentrations of dopamine (DA), serotonin (5‐HT), and their respective metabolites, homovanillic acid (HVA) and 5‐hydroxyindole‐acetic acid (5‐HIAA), were measured in vivo by dialysis of rat striatum and hippocampus. During the ischaemic period, striatal DA content increased (250‐fold basal concentrations) with parallel but much less marked increases of both striatal and hippocampal 5‐HT content (eight‐ to 10‐fold). Baseline values were restored during reperfusion. Subsequent increases of DA and 5‐HT levels on cardiac arrest were comparable after both sham operation and ischaemia. Significant decreases of HVA and 5‐HIAA levels were observed following ischaemia or cardiac arrest. The differential effects of ischaemia on DA and 5‐HT suggest selective alterations in disposition or metabolism of the two transmitters and that dopaminergic neurones may be more vulnerable to ischaemic insults.