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Gene Expression of Tyrosine Hydroxylase in the Developing Fetal Brain
Author(s) -
Coulon J. F.,
Biguet N. Faucon,
Cavoy A.,
Delacour J.,
Mallet J.,
David J. C.
Publication year - 1990
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1990.tb03154.x
Subject(s) - tyrosine hydroxylase , aromatic l amino acid decarboxylase , tyrosine , tyrosine 3 monooxygenase , dopamine , medicine , endocrinology , hypothalamus , gene expression , biology , enzyme , fetus , messenger rna , biochemistry , gene , pregnancy , genetics
Tyrosine hydroxylase, aromatic l‐amino‐acid decarboxylase, and dopamine β‐hydroxylase activities were studied in the developing fetal rat brain. A delay of 2–3 days between the detection of the tyrosine hydroxylase and the aromatic l‐amino‐acid decarboxylase and dopamine β‐hydroxylase activities was observed. For this reason, the expression of tyrosine hydroxylase mRNA was studied. Tyrosine hydroxylase mRNA was visualized in the whole brain from 13 days of gestation, but the largest increase of the expression was observed in the hypothalamus. These results are discussed in terms of the relative gene expressions of the three enzymes involved in the biosynthesis of catecholamines and phenolamines in nervous tissues.