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In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1 H Magnetic Resonance Spectroscopy
Author(s) -
Petroff Ognen A. C.,
Novotny Edward J.,
Ogino Takashi,
Avison Malcolm,
Prichard James W.
Publication year - 1990
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1990.tb01947.x
Subject(s) - in vivo , ethanol , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , spectroscopy , chemistry , functional magnetic resonance spectroscopy of the brain , analytical chemistry (journal) , magnetic resonance imaging , chromatography , biochemistry , physics , biology , medicine , microbiology and biotechnology , radiology , quantum mechanics
In vivo 1 H magnetic resonance spectroscopy was used to measure the cerebral ethanol concentration in the rabbit after both intraarterial and intragastric administration. There was good agreement between cerebral and blood ethanol concentrations at all times after administration by either route. Cerebral ethanol levels, measured using in vivo 1 H spectroscopy, agreed well with those measured in perchloric acid extracts of brain, analyzed by both high‐resolution 1 H spectroscopy and gas chromatography. Ethanol may be useful as an indicator to measure cerebral blood flow by 1 H spectroscopy and chemical shift‐selective magnetic resonance imaging.