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Pyruvate Dehydrogenase Interactions with Peripheral‐Type Benzodiazepine Receptors
Author(s) -
Daval JeanLuc,
Post Robert M.,
Marangos Paul J.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb10904.x
Subject(s) - pyruvate dehydrogenase complex , benzodiazepine , receptor , gabaa receptor , mitochondrion , peripheral , biochemistry , chemistry , function (biology) , biology , enzyme , microbiology and biotechnology , medicine
Although peripheral‐type benzodiazepine recognition sites have been demonstrated in the brain of various species, the precise identity and function of the peripheral benzodiazepine receptor have not been established yet. In light of the recent demonstration of the mitochondrial localization of this receptor and its potential role in intermediary metabolism, we investigated the relationship between the benzodiazepines and the enzyme pyruvate dehydrogenase (PDH), a component of the mitochondrial membrane. The results obtained in the present study demonstrate a specific interaction between PDH and the ligands for the peripheral‐type benzodiazepine receptor, which might account for their effects on cell growth and differentiation.