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Effects of Apomorphine on In Vivo Release of Dopamine and Its Metabolites in the Prefrontal Cortex and the Striatum, Studied by a Microdialysis Method
Author(s) -
Ozaki Norio,
Nakahara Daiichiro,
Miura Hideki,
Kasahara Yomishi,
Nagatsu Toshiharu
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb09253.x
Subject(s) - microdialysis , homovanillic acid , dopamine , apomorphine , striatum , prefrontal cortex , chemistry , 3,4 dihydroxyphenylacetic acid , autoreceptor , in vivo , dopaminergic , neuroscience , endocrinology , biology , biochemistry , agonist , serotonin , receptor , cognition , microbiology and biotechnology
The effects of apomorphine (0.1‐2.5 mg/kg) on release of endogenous dopamine and extracellular levels of 3.4‐dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the prefrontal cortex and the striatum were examined in vivo by a microdialysis method. Apomorphine significantly reduced release of dopamine and the extracellular levels of dopamine metabolites, DOPAC and HVA, not only in the striatum, but also in the prefrontal cortex. These findings indicate that dopamine autoreceptors modulate in vivo release of dopamine in the prefrontal cortex.