Premium
Alterations in Protective Enzymes Against Peroxidation in the Central and Peripheral Nervous System of Control and Dysmyelinating Mutant Mice
Author(s) -
Cloëz Isabelle,
Tayarani Ivan,
Morel Frédérique,
Bourre JeanMarie
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb09179.x
Subject(s) - glutathione reductase , glutathione peroxidase , cerebellum , cerebrum , catalase , superoxide dismutase , glutathione , central nervous system , biochemistry , chemistry , endocrinology , medicine , peroxidase , peripheral nervous system , antioxidant , biology , enzyme
The activities of peroxide‐detoxifying enzymes such as superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalase were measured in the nervous system of neurological dysmyelinating mutants: quaking ( Qk ), shiverer ( Shi ), and trembler ( Tr ) mice. Cu/Zn–SOD activity was higher in the cerebellum of Qk and Shi mice (by 53% and 106%, respectively) in comparison with controls, but it was the same in the cerebellum of Tr mice and their corresponding controls. In contrast, there was no difference in the level of Cu/Zn–SOD activity in the cerebrum of Qk, Shi , and Tr mice and their respective controls. Mn–SOD activity was the same among all the mutants compared to control animals in both cerebrum and cerebellum. In Shi cerebellum, glutathione peroxidase and glutathione reductase activities were slightly decreased (a 21.6% and a 13.2% diminution, respectively), whereas catalase activity in cerebrum and cerebellum was the same among mutants and control mice. In the sciatic nerve from Tr mice, all the enzymatic activities were enhanced: sixfold increase for total SOD, and 2.4‐fold, 3.5‐fold, and 1.8‐fold increase for glutathione peroxidase, glutathione reductase, and catalase, respectively.