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Cerebrospinal Fluid Parameters in Healthy Volunteers During Serial Lumbar Punctures
Author(s) -
Menachem E. Ben,
Persson L.,
Schechter P. J.,
Haegele K. D.,
Huebert N.,
Hardenberg J.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb09166.x
Subject(s) - cerebrospinal fluid , lumbar , lumbar puncture , medicine , pathology , anatomy
Lumbar punctures were performed on four occasions over a 5‐day period (8:30 a.m. on days 1, 3, and 5; 2: 30 p.m. on day 2) on 10 normal volunteers (five of each sex; mean age, 27.7 years) to assess, with repeated sampling, the day‐to‐day variation of selected CSF parameters. Two subjects abstained from the lumbar puncture on day 5 due to headache after the third puncture. Lumbar CSF was analyzed for concentrations of free and total γ‐aminobutyric acid (GABA), homocarnosine, homovanillic acid (HVA), 5‐hydroxyindoleacetic acid (5‐HIAA), total protein, albumin, and immunoglobulin (Ig)G. No significant concentration differences were found between the afternoon and next morning samples. No differences were found in concentrations of free GABA, total GABA, homocarnosine, 5‐HIAA, or albumin across the study. In contrast, HVA concentrations significantly increased by day 5, whereas total protein and IgG decreased during the study. The most likely explanation for these changes involves the known concentration gradients in the CSF column.