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Stimulation‐Induced Release of Coexistent Transmitters in the Prefrontal Cortex: An In Vivo Microdialysis Study of Dopamine and Neurotensin Release
Author(s) -
Bean Andrew J.,
During Matthew J.,
Roth Robert H.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb07384.x
Subject(s) - microdialysis , neurotensin , dopamine , medial forebrain bundle , prefrontal cortex , stimulation , neuroscience , in vivo , catecholamine , extracellular , chemistry , medicine , striatum , biology , neuropeptide , biochemistry , receptor , cognition , microbiology and biotechnology
Extracellular fluid levels of dopamine and neurotensin in the rat prefrontal cortex were measured using in vivo microdialysis. Electrical stimulation of the median forebrain bundle resulted in increased release of both dopamine and neurotensin from the prefrontal cortex. Thus, stimulation of neurons in which dopamine and neurotensin are colocalized can evoke the in vivo release of both substances.