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Chronically Administered Lithium Alters Neither myo ‐Inositol Monophosphatase Activity nor Phosphoinositide Levels in Rat Brain
Author(s) -
Honchar Michael P.,
Ackermann Karen E.,
Sherman William R.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb07374.x
Subject(s) - lithium (medication) , inositol , chemistry , endocrinology , medicine , pharmacology , biology , receptor , biochemistry
Abstract: Rats were exposed to either 29 consecutive days of LiCl injections or 27 and 39 days of dietary Li 2 C0 3 , followed by injected LiCl at the end of the diet to insure a constant level of exposure to the drug. At the end of the period of chronic exposure to lithium, the rats were sacrificed and brain myo ‐inositol‐1‐phosphate phosphohydrolase ( myo ‐inositol monophosphatase) activity was measured. In none of the experiments was there any difference in the lithium‐sensitive activity toward myo ‐inositol monophosphatase when comparing the control and chronic groups. These brains and those from another group of rats that had been given Li 2 C0 3 in their diet for 41 days, followed by 7 additional days of LiCl injections, were also examined for changes in the levels of the phosphoinositides. No reproducible differences in the absolute tissue levels of those lipids were found when control and chronic lithium groups were compared. These results are contrary to published reports which suggest that myo ‐inositol monophosphatase activity increases and that the phospha‐tidylinositol level decreases in rat brain as a result of chronic administration of lithium.