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Changes in Amino Acid Contents in the Spinal Cord and Brainstem of Rats with Experimental Autoimmune Encephalomyelitis
Author(s) -
Honegger Conrad G.,
Krenger Werner,
Langemann Helen
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb07351.x
Subject(s) - taurine , brainstem , spinal cord , encephalomyelitis , experimental autoimmune encephalomyelitis , amino acid , glycine , glutamate receptor , medicine , chemistry , choline chloride , neurotransmitter , endocrinology , biochemistry , biology , central nervous system , neuroscience , receptor
The effects of experimental autoimmune encephalomyelitis (attack and recovery) on levels of six amino acids have been investigated in nine regions of the Lewis rat spinal cord between segments C3 and Col and in the brainstem. Amino acids were analyzed by separation of their 4′‐dimeth‐ylaminoazobenzene‐4‐sulfonyl chloride derivatives on a re‐versed‐phase column using a ternary gradient. Glutamate and γ‐aminobutyric acid were reduced by 10‐30% in all segments during the attack, whereas taurine, lysine, glutami|ne, and glycine were all greatly increased (up to 300%). Most values except those of taurine, as well as glutamate in certain segments, returned to normal on recovery. Because some of these compounds have neurotransmitter function, these changes may contribute to the neurological symptoms of experimental autoimmune encephalomyelitis.