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Mouse Brain c‐fos mRNA Distribution Following a Single Electroconvulsive Shock
Author(s) -
Daval JeanLuc,
Nakajima Takashi,
Gleiter Christoph H.,
Post Robert M.,
Marangos Paul J.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb07285.x
Subject(s) - in situ hybridization , cerebellum , hippocampus , c fos , neuroscience , electroconvulsive shock , stimulation , endocrinology , hypothalamus , messenger rna , cerebral cortex , medicine , biology , cortex (anatomy) , electroconvulsive therapy , central nervous system , limbic system , chemistry , gene expression , biochemistry , gene
The regional distribution of c‐fos mRNA in the mouse brain has been investigated by in situ hybridization autoradiography after seizures induced by an acute electroconvulsive shock (ECS). ECS led to a widespread induction of the proto‐oncogene c‐fos in the brain, with highest concentrations in discrete areas within the limbic system and also in the hypothalamus and cerebellum. The mild stress of sham treatment in earclipped animals induced a weaker and qualitatively different pattern of c‐fos mRNA expression involving the cortex, hippocampus, and cerebellum. These data suggest the usefulness of c‐fos in situ hybridization as a marker of neuronal stimulation and in mapping a range of effects from a mild stress to the robust changes of an electroconvulsive seizure.