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Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia
Author(s) -
Deakin J. F. W.,
Slater P.,
Simpson M. D. C.,
Gilchrist A. C.,
Skan W. J.,
Royston M. C.,
Reynolds G. P.,
Cross A. J.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb07257.x
Subject(s) - glutamatergic , neuroscience , glutamate receptor , dopaminergic , temporal cortex , amygdala , nmda receptor , cortex (anatomy) , psychology , dopamine , biology , medicine , receptor
Glutamatergic mechanisms have been investigated in postmortem brain samples from schizophrenics and controls. D‐[ 3 H]Aspartate binding to glutamate uptake sites was used as a marker for glutamatergic neurones, and [ 3 H]kainate binding for a subclass of postsynaptic glutamate receptors. There were highly significant increases in the binding of both ligands to membranes from orbital frontal cortex on both the left and right sides of schizophrenic brains. The changes are unlikely to be due to antemortem neuroleptic drug treatment, because no similar changes were recorded in other areas. A predicted left‐sided reduction in D‐[ 3 H]aspartate binding was refuted at 5% probability, but not at 10%. Previously reported high concentrations of dopamine in left amygdala were strongly associated with low concentrations of D‐[ 3 H]aspartate binding in left polar temporal cortex in the schizophrenics. The findings are compatible with an overabundant glutamatergic innervation of orbital frontal cortex in schizophrenia. The results also suggest that schizophrenia may involve left‐sided abnormalities in the relationship between temporal glutamatergic and dopaminergic projections to amygdala.