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Cloning of a Putative Neuronal Nicotinic Acetylcholine Receptor Subunit
Author(s) -
Isenberg Keith E.,
Meyer Grant E.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb02553.x
Subject(s) - nicotinic acetylcholine receptor , acetylcholine receptor , complementary dna , protein subunit , cdna library , nicotinic agonist , gamma aminobutyric acid receptor subunit alpha 1 , biology , ganglion type nicotinic receptor , microbiology and biotechnology , biochemistry , receptor , g alpha subunit , gene
A cDNA clone was isolated from a rat superior cervical ganglion cDNA library with an oligonucleotide that hybridized to muscle‐like nicotinic acetylcholine receptor (nAChR) subunit cDNA. The deduced amino acid sequence possesses characteristics expected of a nAChR subunit that does not bind acetylcholine, in addition to distinctive features such as unique cysteine residues and N‐linked glycosylation sites.