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Pharmacological and Functional Heterogeneity of Astrocytes: Regional Differences in Phospholipase C Stimulation by Neuromediators
Author(s) -
ElEtr M.,
Cordier J.,
Torrens Y.,
Glowinski J.,
Prémont J.
Publication year - 1989
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1989.tb02551.x
Subject(s) - cerebral cortex , striatum , astrocyte , neuroscience , stimulation , midbrain , cortex (anatomy) , chemistry , biology , central nervous system , dopamine
Carbamylcholine stimulated phospholipase C activity in astrocytes in primary culture from the mesencephalon but not from the striatum or cerebral cortex of the mouse embryo. An α 1 ‐adrenergic‐mediated response was observed in all astrocyte populations. 2‐Chloroadenosine potentiated the α 1 ‐adrenergic response in mesencephalic and striatal astrocytes but not in cortical astrocytes. It also stimulated the carbamylcholine‐evoked response in mesencephalic astrocytes. Through cell‐cell cooperation, 2‐chloroadenosine potentiated the neuronal carbamylcholine‐evoked activation of phospholipase C in homotopic cocultures (neuroglial) from the striatum but not in homotopic cocultures (neuroglial) from the cerebral cortex or in heterotopic cocultures (cortical astrocytes‐striatal neurons; striatal astrocytes‐cortical neurons).