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Possible Involvement of Glutathione S ‐Transferases in the Cell Growth of C6 Astroglioma Cells
Author(s) -
Senjo Masanori,
Ishibashi Teruo
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb13244.x
Subject(s) - glutathione , glutathione s transferase , cell growth , glutathione transferase , cell cycle , enzyme , cell , caffeic acid , cell culture , transferase , biochemistry , glutathione reductase , biology , isozyme , chemistry , antioxidant , genetics , glutathione peroxidase
The changes of glutathione S ‐transferase activity were investigated using rat brain astroglioma C6 cells that were synchronized at different phases of the cell cycle. The enzyme showed two significant activity peaks at G 2 and G 1 phases. Furthermore, when C6 glioma cells were exposed to a culture medium supplemented with specific glutathione S ‐transferase inhibitors, ethacrynic acid and caffeic acid, cell growth was remarkably suppressed. These results suggest that glutathione S ‐transferases may be closely related to the mechanism of cell proliferation.