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Neuritic Plaque Amyloid in Alzheimer's Disease Is Highly Racemized
Author(s) -
Shapira Raymond,
Austin Garth E.,
Mirra Suzanne S.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb13231.x
Subject(s) - senile plaques , amyloid (mycology) , alzheimer's disease , disease , neuroscience , medicine , biology , pathology
Neuritic plaque core amyloid protein in Alzheimer's disease brain tissue was investigated for the extent of amino acid racemization. Long‐lived human proteins exhibit racemization of certain amino acids over the course of a human lifetime. Purified core amyloid was found to contain relatively large proportions of D‐aspartate and D‐serine, suggesting that neuritic plaque amyloid is derived from a long‐lived precursor protein. Alternatively, racemization of protein amino acids may be abnormally accelerated in Alzheimer's disease.