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Localization of the Novel Neuropolypeptide h 3 in Subsets of Tissues from Different Species
Author(s) -
Bollengier F.,
Mahler A.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb10594.x
Subject(s) - isoelectric focusing , isoelectric point , brain tissue , biology , nervous tissue , muscle tissue , microbiology and biotechnology , biochemistry , anatomy , enzyme , neuroscience
Recently we reported the isolation and partial biochemical characterization of a novel polypeptide, h 3 , from the human brain and liver. Thin‐layer isoelectric focusing showed that the polypeptide was ubiquitously distributed throughout the human brain. Immunophosphatase transfer electrophoresis showed that this protein was localized in several mammalian species and different tissues. In addition, h 3 or h 3 ‐like protein was demonstrated in subsets of tissues from one avian species. Protein h 3 was present in epithelial and muscular tissue, as well as in nervous tissue; however, for all species investigated, it was most abundant in CNS and muscle.