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Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase
Author(s) -
Darmon Michèle C.,
Guibert Bernard,
Leviel Vincent,
Ehret Mireille,
Maitre Michel,
Mallet Jacques
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb04871.x
Subject(s) - tryptophan hydroxylase , tryptophan , sequence (biology) , biology , biochemistry , chemistry , genetics , serotonin , amino acid , receptor , serotonergic
Two full‐length cDNA clones that encode functional rat tryptophan hydroxylase (EC 1.14.16.4), the key enzyme in serotonin synthesis, have been isolated from a rat pineal gland library. These tv/o clones correspond to the 1.8 and 4‐kilobase mRNA species, respectively. They contain the same coding sequence corresponding to a 51,010 dalton protein and differ in the length of their 3’ untranslated regions.