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Regional Changes in the Cellular Level of Adenine Nucleotides in Ischemic Rat Brain Subjected to Single Embolization
Author(s) -
Yamada Kenji,
Uozumi Tohru,
Kawasaki Takashi,
Yamada Kazuo,
Sogabe Takashi,
Ohta Keiji
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb04847.x
Subject(s) - hemiparesis , embolization , hippocampus , ischemia , adenine nucleotide , diaschisis , medicine , endocrinology , striatum , nucleotide , anesthesia , chemistry , cerebellum , biochemistry , surgery , angiography , gene , dopamine
Regional changes in adenine nucleotides in the rat brain were studied after 1 h of ischemia produced by the embolization method. The animals were divided into three groups according to neurological symptoms: sham‐operation group, group A (hemiparesis only), and group B (he‐miparesis with unconsciousness). Marked ATP depletion was detected in the hippocampus on the embolized side and extended to the other regions on the same side in group B. The results suggest that this damage in regional energy metabolism arises from regional reduction in blood flow and/or tissue vulnerability. ATP levels in the hypothalamus, hippocampus, and striatum on the opposite side of embolization decreased markedly in group B, and may be caused by extension of brain edema or diaschisis.