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Contents of Cystathionine and Taurine in Various Cerebellar Regions of dl‐Propargylglycine‐Treated Rats
Author(s) -
Kodama Hiroyuki,
Sasaki Keiko,
Mizobuchi Noriko,
Kikuchi Reiji
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb03066.x
Subject(s) - cystathionine beta synthase , taurine , endocrinology , medicine , cerebellum , chemistry , body weight , biochemistry , biology , methionine , amino acid
The contents of cystathionine and taurine, as well as cystathionine β‐synthase activity, in various cerebellar regions and pineal body of normal and dl‐propargylgly‐cine‐treated rats were measured. The contents of cystathionine and taurine were found to be distributed unevenly in cerebellar regions of brain of both normal and dl‐propargylglycine‐treated rats. The content of cystathionine in each cerebellar region and pineal body increased gradually when the dose of DL‐propargylglycine was increased from 10 mg to 30 mg per 200 g body weight. On the other hand, taurine content in each cerebellar region and pineal body decreased with the administration of 30 mg of dl‐propargylglycine per 200 g body weight. The contents of cystathionine and taurine were greater in the pineal body than in various cerebellar regions. The activity of cystathionine β‐synthase was also distributed unevenly in various cerebellar regions of normal rat brain, and was unaltered following treatment of rats with dl‐propargylglycine.