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Protein Turnover and Growth of the Rat Brain from the Foetus to Old Age
Author(s) -
Goldspink David F.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb03017.x
Subject(s) - protein turnover , fetus , biology , neuroscience , endocrinology , biochemistry , pregnancy , protein biosynthesis , genetics
Growth of the rat brain was studied between 16 days of foetal life and old age (105 weeks). Developmental changes in cerebral RNA, DNA, and protein contents are described. The age‐related decline in brain growth rates correlates with progressive decreases in the fractional rates of protein synthesis (from 58 to 6.8% per day) and break down (from 36.4 to 4.1% per day).