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N 6 ‐Cyclohexyladenosine Inhibits Veratridine‐Stimulated Na Uptake by Rat Brain Synaptosomes
Author(s) -
Simoes A. P.,
Oliveira P. C.,
Sebastião A. M.,
Ribeiro J. A.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02997.x
Subject(s) - veratridine , adenosine , chemistry , xanthine , synaptosome , sodium , incubation , deoxyadenosine , adenosine receptor , medicine , endocrinology , biophysics , sodium channel , biochemistry , receptor , biology , in vitro , enzyme , organic chemistry , agonist
The effect of the stable adenosine analogue, N 6 ‐cyclohexyladenosine, on 22 Na uptake by rat brain synaptosomes stimulated by veratridine was investigated. In the presence of N 6 ‐cyclohexyladenosine, both the initial rate and the maximum sodium uptake were decreased. The inhibitory effect of N 6 ‐cyclohexyladenosine on sodium uptake by synaptosomes after 5 s of incubation with 22 Na was concentration‐dependent, antagonized by 1,3‐dipropyl‐8‐ p ‐sulfophenylxanthine, and attenuated by increasing the concentration of veratridine. The possibility that the adenosine analogue, by activating a xanthine‐sensitive adenosine receptor, can operate inhibition of the voltage‐dependent sodium channels is discussed.