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Cyclic Nucleotides and the Activity of Glia Maturation Factor in the Hypoplastic Cerebellum of Developing Jaundiced Gunn Rats
Author(s) -
Aono Sachiko,
Kato Taiji,
Tanaka Ryo,
Sato Hiroshi,
Semba Reiji,
Kashiwamata Shigeo
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02970.x
Subject(s) - nucleotide , medicine , endocrinology , cyclic nucleotide , cerebellum , cyclic gmp , biology , period (music) , body weight , chemistry , biochemistry , physics , nitric oxide , gene , acoustics
Developmental changes of cyclic nucleotides were studied in the hypoplastic cerebellum of jaundiced Gunn rats over the period of postnatal days 8 to 30. The mitogenic activity of glia maturation factor was also measured at day 15. In jaundiced homozygotes( jj ), the amount of cyclic GMP on a protein basis was not significantly different from that in control heterozygotes ( j+ ) at either day 8 or 15, but at day 30 it was reduced to about 19% of the control. On the other hand, a lowered nucleotide level on a wet weight basis in jj rats was already statistically significant at day 15. In contrast to cyclic GMP, the rates of increase of cyclic AMP on a wet weight basis were almost the same in the two groups of rats, but the nucleotide levels on a protein basis at days 15 and 30 were a little, but significantly, higher in jj rats than in j+ rats. The activity of glia maturation factor in jj rats was found to be 1.5‐3 times as high as that in j+ rats. Possible implications of the present results are discussed.