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Inability of [ 125 I]Sar 1 , Ile 8 ‐Angiotensin II to Move Between the Blood and Cerebrospinal Fluid Compartments
Author(s) -
Harding J. W.,
Sullivan M. J.,
Hanesworth J. M.,
Cushing L. L.,
Wright J. W.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02946.x
Subject(s) - cerebrospinal fluid , renin–angiotensin system , angiotensin ii , medicine , endocrinology , chemistry , receptor , biology , blood pressure
The angiotensin II competitive antagonist [ 125 I]‐Sar 1 ,Ile 8 ‐angiotensin II was not transported from the vascular space to the cerebroventricular space in either intact or nephrectomized rats. In addition [ 125 I]Sar 1 ,Ile 8 ‐angiotensin II lacked the capacity to move in the opposite direction over a 20‐min collection period following cerebroventricular infusion. These data suggest that angiotensins lack the capacity to move freely between the blood and cerebrospinal fluid compartments and are consistent with the notion that blood‐borne and cerebroventricular angiotensins access different receptor populations.