Premium
A 140‐Kilodalton Protein Is Released from Cultured Astrocytes by Phosphatidylinositol Phospholipase C
Author(s) -
Amblard F.,
He J.T.,
Barbet J.,
Goridis C.,
Prochiantz A.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02937.x
Subject(s) - kilodalton , phosphatidylinositol , phospholipase c , astrocyte , microbiology and biotechnology , biochemistry , in vitro , biology , phospholipase , glycolipid , chemistry , signal transduction , enzyme , gene , central nervous system , neuroscience
Astrocytes in culture synthesize a 140‐kilodalton (140‐kD) protein (protein 140) that is released into the medium on incubation with phosphatidylinositol phospholipase C. This molecule therefore belongs to the class of proteins anchored to the external side of the cell membrane through a glycolipid moiety. Protein 140 is present in astrocyte cultures derived from two different regions of the brain and is not expressed by neurons in vitro. It differs from neuronal cell adhesion molecule 120 or 140 and is probably identical to a protein of 140 kD present in C6 glioma cells.