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Assay of 2‐Hydroxyputrescine in Various Regions of Rat Brain by Gas Chromatography‐Mass Spectrometry
Author(s) -
Noto Tadashi,
Hasegawa Takeshi,
Hashimoto Hiromichi,
Nakajima Teruo
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02933.x
Subject(s) - medulla oblongata , striatum , midbrain , cerebellum , hippocampus , cerebral cortex , hypothalamus , chemistry , cortex (anatomy) , medulla , neuroscience , biology , central nervous system , endocrinology , dopamine
2‐Hydroxyputrescine in seven regions of single rat brains was measured with a sensitive, specific assay by gas chromatography‐mass spectrometry. The regions were the cerebral cortex, cerebellum, medulla oblongata, hypothalamus, striatum, hippocampus, and midbrain. The level of 2‐hydroxyputrescine was very high in the cerebral cortex and cerebellum, high in the medulla oblongata, hypothalamus, and hippocampus, and low in the striatum and mid‐brain. The level of 2‐hydroxyputrescine in the cerebellum was significantly higher than in the striatum and midbrain.