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Brain Quinolinic Acid in Huntington's Disease
Author(s) -
Reynolds Gavin P.,
Pearson Sally J.,
Halket John,
Sandier Merton
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02503.x
Subject(s) - quinolinic acid , huntington's disease , putamen , neurotoxin , metabolite , endogeny , medicine , cerebral cortex , endocrinology , neuroscience , chemistry , biology , tryptophan , disease , biochemistry , amino acid
Abstract: Concentrations of the endogenous neurotoxic tryptophan metabolite, quinolinic acid (QA), were measured in postmortem brain tissue obtained from patients with Huntington's disease (HD) and matched controls, using a gas chromatography/mass spectrometry method. There was no significant difference in either the putamen or the frontal cortex between the HD and control groups. These results do not support the hypothesis that increased QA is responsible for neuronal degeneration in HD.