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Effect of Ethanol Administration on Striatal D 1 and D 2 Dopamine Receptors
Author(s) -
Hruska Robert E.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02499.x
Subject(s) - receptor , dopamine , ethanol , dopamine receptor d2 , dopamine receptor , medicine , endocrinology , chemistry , striatum , pharmacology , biology , biochemistry
Chronic in vivo exposure of rats to ethanol in a complete liquid diet for 14 or 21 days produced a behavioral tolerance to the acute injection of ethanol. After 21 days, but not 14 days, of chronic exposure, there was a significant increase in the maximum density of striatal D 1 and D2 dopamine receptors without a change in these receptors' affinities. A 24‐h withdrawal from the 21‐day exposure did not alter the observed increase in density. Both the level and duration of ethanol exposure appear to be important variables for demonstration of an increase in striatal D 1 and D 2 dopamine receptors.