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Effect of Taurine on Calcium Accumulation in Resting and Depolarised Insect Synaptosomes
Author(s) -
Whitton Peter S.,
Nicholson Russell A.,
Strang Robin H. C.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb02473.x
Subject(s) - taurine , calcium , insect , synaptosome , chemistry , biology , neuroscience , biophysics , biochemistry , endocrinology , medicine , ecology , organic chemistry , amino acid
The effect of taurine (2‐aminoethanesulphonic acid) on 45 Ca 2+ accumulation in resting and depolarised synaptosomes obtained from the locust Schistocerca americana gregaria was studied. Taurine reduced 45 Ca 2+ accumulation in resting synaptosomes, and this effect was more pronounced when synaptosomes were depolarised with either high [K + ] or veratridine. Veratridine‐induced 45 Ca 2+ accumulation was not affected by either γ‐aminobutyric acid or leucine, but was reduced by both verapamil and tetrodotoxin.