Premium
Primary Structure of Neuromedin U from the Rat
Author(s) -
Conlon J. M.,
Domin J.,
Thim L.,
DiMarzo V.,
Morris H. R.,
Bloom S. R.,
Thim L.,
DiMarzo V.,
Morris H. R.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01837.x
Subject(s) - protein primary structure , peptide , ileum , amino acid , neuropeptide , peptide sequence , chemistry , medicine , biochemistry , endocrinology , biology , receptor , gene
The primary structure of neuromedin U from the rat ileum was established as: Tyr‐Lys‐Val‐Asn‐Glu 5 ‐Tyr‐Gln‐Gly‐Pro‐Val 10 ‐Ala‐Pro‐Ser‐Gly‐Gly 15 ‐Phe‐Phe‐Leu‐Phe‐Arg 20 ‐Pro‐Arg‐Asn‐NH 2 . There was no evidence for microheterogeneity. This amino acid sequence contains two deletions and nine substitutions compared with the neuromedin U‐25 from the pig. In particular, the replacement of the Arg' 6 ‐Arg 17 processing site in the porcine peptide by Gly 14 ‐Gly 15 in the rat means that a peptide corresponding to neuromedin U‐8 was not found in the rat intestine.