Premium
Thyroxine Injections Do Not Cause Premature Induction of Thymidine Kinase in sg/sg Mice
Author(s) -
Messer Anne
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01825.x
Subject(s) - endocrinology , medicine , thymidine kinase , hormone , thyroid , enzyme , fetus , biology , enzyme inducer , thymidine , pregnancy , biochemistry , immunology , in vitro , virus , genetics , herpes simplex virus
Severe hyperthyroidism from the time of birth causes a premature induction and termination of thymidine kinase activity in the cerebella of wild‐type mice. This leads to elevated enzyme levels at postnatal days 5 and 6, with significantly lower levels by postnatal day 7 (which is actually the time of peak activity in normal animals). In this study, neonatal hyperthyroidism does not have significant effects on postnatal day 5, 6, or 7 enzyme levels in the neurological mutant staggerer. This is consistent with the hypothesis that thyroid hormone exerts its effects via the Purkinje cells, which are reduced in number and grossly stunted in the mutant.