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Spatial Learning Potentiates the Stimulation of Phosphoinositide Hydrolysis by Excitatory Amino Acids in Rat Hippocampal Slices
Author(s) -
Nicoletti F.,
Valerio C.,
Pellegrino C.,
Drago F.,
Scapagnini U.,
Caico P. L.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01804.x
Subject(s) - hippocampal formation , excitatory postsynaptic potential , glutamate receptor , stimulation , neuroscience , chemistry , hippocampus , inhibitory postsynaptic potential , medicine , endocrinology , biochemistry , biology , receptor
Stimulation of phosphoinositide (PI) hydrolysis by excitatory amino acids (glutamate and ibotenate) or nor‐epinephrine was potentiated in hippocampal slices from rats trained in an eight‐arm radial maze, used as a test of spatial learning. No difference in basal or carbamylcho‐line‐stimulated PI hydrolysis was found between control and trained animals. An increased PI response to excitatory amino acids and norepinephrine was not found in hippocampal slices prepared from animals trained in a shock conditioning avoidance test. These results suggest a possible involvement of specific glutamate receptors coupled with PI hydrolysis in the synaptic mechanisms underlying formation and/or storage of spatial memory.