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Vascular Perfusion and Blood‐Brain Glucose Transport in Acute and Chronic Hyperglycemia
Author(s) -
Harik Sami I.,
LaManna Joseph C.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01179.x
Subject(s) - medicine , perfusion , cerebral blood flow , endocrinology , diabetes mellitus , blood flow , streptozotocin , blood–brain barrier , central nervous system
We studied the effects of acute and streptozotocin‐induced chronic hyperglycemia on regional brain blood flow and perfusion characteristics, and on the regional transport of glucose across the blood‐brain barrier in awake rats. We found (1) a generalized decrease in regional brain blood flow in both acute and chronic hyperglycemia; (2) that chronic, but not acute, hyperglycemia is associated with a marked and diffuse decrease in brain l‐glucose space; and (3) that chronic hyperglycemia does not alter blood‐to‐brain glucose transport. Taken together, these results suggest that in streptozotocin‐induced chronic hyperglycemia, there is a reduction in the proportion of perfused brain capillaries and/or an alteration in brain endothelial membrane properties resulting in decreased noncarrier diffusion of glucose.