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Effect of Thyroid Hormones on Benzodiazepine Receptors in Neuron‐Enriched Primary Cultures
Author(s) -
Go Tohshin,
Ito Masatoshi,
Okuno Takehiko,
Mikawa Haruki
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01117.x
Subject(s) - receptor , hormone , endocrinology , medicine , triiodothyronine , thyroid hormone receptor , benzodiazepine , chemistry , gabaa receptor , thyroid , neuron , biology , neuroscience
The effect of administration of thyroid hormones on central benzodiazepine receptors was investigated using neuron‐enriched primary cultures obtained from the neo‐pallium of 16‐day‐old embryonic rats. Addition of l‐triio‐dothyronine for 3 days decreased the maximal number of benzodiazepine receptor binding sites without any change in affinity at 10 −5 and 10 −6 M . l‐Thyroxine administered for 3 days had the same effect at 10 −5 M . No significant change was observed over periods of <3 days, a finding indicating that this inhibition was not a direct in vitro effect. This down‐regulation seems to be a direct modulatory effect of thyroid hormones on cerebral cortical neurons. Addition for 3 days of d ‐thyroxine and d‐triiodothyronine, which are physiologically inactive isomers of the thyroid hormones, did not induce any significant alterations in benzodiazepine receptors. The decrease in number of cerebral cortical neuronal benzodiazepine receptors due to l‐isomers of thyroid hormones may be related to the convulsions and anxiety observed in thyrotoxicosis in humans.