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Studies on DNA Damage and Repair in the Mammalian Brain
Author(s) -
Walker A. P.,
Bachelard H. S.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01103.x
Subject(s) - dna damage , dna repair , dna , biology , computational biology , genetics
Methods for studying breaks in DNA strands and their repair, originally developed for prokaryotes and cultured cell lines, have been applied to preparations from rat brain. The relative sensitivities of these methods, which include alkaline sucrose density gradient sedimentation, nucleoid sedimentation, and ADP‐ribosyltransferase assay, are compared.