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Differential Effects of Tachykinins Injected Intranigrally on Striatal Dopamine Metabolism
Author(s) -
Tan DongPing,
Tsou Kang
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01093.x
Subject(s) - eledoisin , striatum , dopamine , endocrinology , medicine , 3,4 dihydroxyphenylacetic acid , substance p , chemistry , dopaminergic , tachykinin receptor , homovanillic acid , biology , neuropeptide , serotonin , receptor
The effects of intranigral injection of kassinin, ele‐doisin, and substance P on striatal dopamine (DA) and 3,4‐dihydroxyphenylacetic acid (DOPAC) contents as well as circling behavior were studied in rats. Kassinin and eledoisin produced a marked dose‐dependent increase of DOPAC concentrations in the ipsilateral striatum, as well as in the number of contralateral circlings. Substance P produced a similar but weaker effect. At the larger dose (5 nmol), the three tachykinins also induced an increase of DA concentrations in the ipsilateral striatum. The rank order of activity was kassinin > eledoisin > substance P. These results suggest that tachykinins stimulated the nigro‐striatal dopaminergic system by accelerating the dopamine metabolism in striatum.