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Effect of High Doses of Dietary Vitamin E on the Concentrations of Vitamin E in Several Brain Regions, Plasma, Liver, and Adipose Tissue of Rats
Author(s) -
Vatassery G. T.,
Brin M. F.,
Fahn S.,
Kayden H. J.,
Traber M. G.
Publication year - 1988
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1988.tb01083.x
Subject(s) - cerebrum , endocrinology , medicine , adipose tissue , vitamin , cerebellum , striatum , vitamin e , tocopherol , alpha tocopherol , vitamin e deficiency , spleen , chemistry , biology , central nervous system , biochemistry , antioxidant , dopamine
The object of this study was to assess the influence of high levels of dietary vitamin E on vitamin E concentrations in specific areas of the brain. Four‐week‐old male rats were fed vitamin E‐deficient, control, and high‐vitamin E (1,000 IU/kg) diets for 4 months. Concentrations of α‐tocopherol in serum, adipose tissue, liver, cerebrum, cerebellum, and striatum were determined by liquid chromatography with fluorescence detection. In the high‐vitamin E group, α‐tocopherol concentrations in cerebrum, cerebellum, and striatum increased uniformly to 1.4‐fold of values in controls; serum, adipose tissue, and liver attained even higher concentrations: 2.2‐, 2.2‐, and 4.6‐fold, respectively, of control values. As observed before, brain levels of α‐tocopherol were somewhat resistant to vitamin E deficiency, in contrast to the peripheral tissues.