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Evidence for Somatostatin‐Containing Fibers Projecting from the Pallidal Complex to the Striatum of the Rat
Author(s) -
Widmann R.,
MensdorffPouilly N.,
Pfaller K.,
Sperk G.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb05748.x
Subject(s) - globus pallidus , striatum , basal ganglia , somatostatin , ventral striatum , kainic acid , neuroscience , chemistry , medicine , biology , endocrinology , central nervous system , dopamine , glutamate receptor , receptor
The origin of afferent somatostatin‐containing fibers terminating in medial and ventral parts of the striatum has been investigated by performing various neuro‐chemical and surgical lesions in the rat. Lesions of the anterior hypothalamus, amygdala, and the hippocampal commissure as well as lesions with 6‐hydroxydopamine and 5,7‐dihydroxytryptamine failed to decrease striatal soma‐tostatin levels. However, thermal coagulation of the globus pallidus or knife‐cut lesions performed ventrally to the striatum resulted in significant decreases in striatal somatostatin content. Analysis of the topographical distribution of somatostatin within the striatum after thermal lesions of the globus pallidus as well as after kainic acid‐induced seizures revealed a preferential loss of the peptide in medial and ventral portions of the striatum, the site of terminating afferent somatostatin nerve fibers. The data suggest that the striatal afferent somatostatin‐containing neurons may originate in the area of the globus pallidus.