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Effect of Quinolinic Acid in the Nucleus Basalis Magnocellularis on Cortical High‐Affinity Choline Uptake
Author(s) -
Metcalf R. H.,
Boegman R. J.,
Quirion R.,
Riopelle R. J.,
Ludwin S. K.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb02911.x
Subject(s) - quinolinic acid , choline , nucleus basalis , chemistry , acetylcholine , nucleus , biochemistry , endocrinology , medicine , biology , neuroscience , cholinergic neuron , amino acid , tryptophan
A transient 45% increase in cortical high‐affinity choline uptake (HACU) was observed after an injection of quinolinic acid (QUIN) into the nucleus basalis magnocellularis (nbM) of the rat. This was followed by a steady decline in choline uptake, which resulted in a 46% decrease by day 7. Specific ( 3 H]hemicholinium‐3 binding to coronal brain sections showed a similar pattern following injections of QUIN into the nbM. The increase in cortical HACU elicited by QUIN appeared to be dose dependent.