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Stimulatory Effect of the D2 Antagonist Sulpiride on Glucose Utilization in Dopaminergic Regions of Rat Brain
Author(s) -
Pizzolato Gilberto,
Soncrant Timothy T.,
Larson Denise M.,
Rapoport Stanley I.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb02910.x
Subject(s) - sulpiride , olfactory tubercle , endocrinology , medicine , nucleus accumbens , haloperidol , dopaminergic , dopamine , dopamine receptor , chemistry , antagonist , diencephalon , habenula , median eminence , hypothalamus , central nervous system , biology , receptor
Local cerebral glucose utilization (LCGU) was measured, using the quantitative autoradiographic [ 14 C]2‐deoxy‐ d ‐glucose method, in 56 brain regions of 3‐month‐old, awake Fischer‐344 rats, after intraperitoneal administration of sulpiride (SULP) 100 mg/kg. SULP, an “atypical” neuroleptic, is a selective antagonist of D2 dopamine receptors. LCGU was reduced in a few nondopaminergic regions at 1 h after drug administration. Thereafter, SULP progressively elevated LCGU in many other regions. At 3 h, LCGU was elevated in 23% of the regions examined, most of which are related to the CNS dopaminergic system (caudate‐putamen, nucleus accumbens, olfactory tubercle, lateral habenula, median eminence, paraventricular hypothalamic nucleus). Increases of LCGU were observed also in the suprachiasmatic nucleus, lateral geniculate, and inferior olive. These effects of SULP on LCGU differ from the effects of the “typical” neuroleptic haloperidol, which produces widespread decreases in LCGU in the rat brain. Selective actions on different subpopulations of dopamine receptors may explain the different effects of the two neuroleptics on brain metabolism, which correspond to their different clinical and behavioral actions.