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2‐Pyrrolidinone in Human Cerebrospinal Fluid: A Major Constituent of Total γ‐Aminobutyric Acid
Author(s) -
Haegele K. D.,
Schwartz J.J.,
Schoun J.,
Schmitt A. H.,
Schechter P. J.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb01006.x
Subject(s) - cerebrospinal fluid , aminobutyric acid , chemistry , hydrolysis , biochemistry , chromatography , fraction (chemistry) , biology , neuroscience , receptor
Abstract: 2‐Pyrrolidinone, the lactam of γ‐aminobutyric acid (GABA), is identified as the major constituent of total GABA in human CSF. Structural elucidation was done by mass spectrometry. In lumbar CSF of four patients, 2‐pyr‐rolidinone represented about 54% of GABA found after acid hydrolysis, thus accounting for essentially all of the hitherto unknown GABA fraction in CSF.