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Primary Structure and Tissue Distribution of Guinea Pig Gastrin‐Releasing Peptide
Author(s) -
Shaw C.,
Thim L.,
Conlon J. M.
Publication year - 1987
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1987.tb00998.x
Subject(s) - gastrin releasing peptide , gastrin , edman degradation , guinea pig , peptide , stomach , small intestine , chemistry , biology , medicine , peptide sequence , bombesin , biochemistry , endocrinology , neuropeptide , secretion , receptor , gene
The primary structure of gastrin‐releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin‐releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin‐releasing peptide and its COOH‐terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin‐releasing peptide. Within the small intestine, highest concentrations of gastrin‐releasing peptide‐like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.